CitationDownload to EndNote Citation Manager| Title | Screening Potential Alllelle-Frequency Disequilibrium in Data from Affymetrix Gene Expression Arrays |
| Author | Manhong Dai; Yongjia Wang; Elzbieta Sliwerska; Margit Burmeister; Stanley J. Watson; Huda Akil; Fan Meng |
| Year | 2005 |
| Journal | Advances in Bioinformatics and its Applications Series in Mathematical Biology and Medicine |
| Voume | 8 |
| Page | 132-139 |
| Abstract | The popular Affymetrix human gene expression analysis arrays contain oligonucleotide probes that overlap with thousands of known single nucleotide polymorphism sites. These allele-specific probes provide the possibility of screening allele-frequency difference in existing GeneChip data. We explored analysis procedures that can detect allele-specific signals of known SNPs in different sample groups. Our analysis results and independent genotyping data show it is feasible to utilize these allele-specific probes to screen potential allele-frequency disequilibrium in large-scale GeneChip-based expression profiling projects. |
| Link | http://www.worldscibooks.com/lifesci/5746.html |
| Cited By | Click to see which papers cited this paper. |
