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Title	Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Author	Choudary, P. V.; Molnar, M.; Evans, S. J.; Tomita, H.; Li, J. Z.; Vawter, M. P.; Myers, R. M.; Bunney,, W. E., Jr.; Akil, H.; Watson, S. J.; Jones, E. G.
Year	2005
Journal	PNAS
Page	15653-15658
Abstract	Contributed by E. G. Jones, September 9, 2005Abnormalities in L-glutamic acid (glutamate) and GABA signal transmission have been postulated to play a role in depression, but little is known about the underlying molecular determinants and neural mechanisms. Microarray analysis of specific areas of cerebral cortex from individuals who had suffered from major depressive disorder demonstrated significant down-regulation of SLC1A2 and SLC1A3, two key members of the glutamate/neutral amino acid transporter protein family, SLC1. Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glutamate to nontoxic glutamine was significantly decreased. Together, these changes could elevate levels of extracellular glutamate considerably, which is potentially neurotoxic and can affect the efficiency of glutamate signaling. The astroglial distribution of the two glutamate transporters and L-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder. The same cortical areas displayed concomitant up-regulation of several glutamate and GABAA receptor subunits, of which GABAA{alpha}1 and GABAA{beta}3 showed selectivity for individuals who had died by suicide, indicating their potential utility as biomarkers of suicidality. These findings point to previously undiscovered molecular underpinnings of the pathophysiology of major depression and offer potentially new pharmacological targets for treating depression.
Link	http://www.pnas.org/cgi/content/abstract/0507901102v1
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